ROANOKE TIMES

                         Roanoke Times
                 Copyright (c) 1995, Landmark Communications, Inc.

DATE: THURSDAY, November 16, 1995                   TAG: 9511160044
SECTION: NATL/ITNL                    PAGE: A-11   EDITION: METRO 
SOURCE: KENNETH CHANG LOS ANGELES TIMES
DATELINE: LOS ANGELES                                LENGTH: Medium


HARDY SEED GIVES HOPE ON AGING

After sleeping for 12 centuries at the bottom of a Chinese lake, a lotus seed sprouted under the care of a UCLA botanist, promising insight into how to slow the aging process.

The seed is thought to be the oldest known to germinate, scientists reported. Should researchers discover the secrets of the lotus - a sacred plant that in Buddhism symbolizes purity and longevity - the benefits could span from hardier crop seeds to a skin cream that thwarts wrinkles.

``Life can be much longer than we ever expected,'' said UCLA plant physiologist Jane Shen-Miller, lead author of the research article that appears in the November issue of the American Journal of Botany. ``We certainly have much to learn about how [lotus seeds] can survive 1,000 years of rest.''

Shen-Miller acquired seven of the lotus seeds, which look like dark brown, peanut-sized footballs, while visiting the Beijing Institute of Botany in 1982. Chinese botanists had unearthed the seeds several decades earlier from a dry lake bed.

The next year, Shen-Miller soaked four of the seeds in water after filing off part of their hard outer husks to allow moisture to reach the partly dried-out centers. Each day, she peered at them.

``Then on the fourth day, the lips started to open, and I saw a little green thing,'' Shen-Miller said Monday. ``It was overwhelming.''

According to one of Shen-Miller's collaborators, UCLA biochemist Steven Clarke, ``It's almost as if you took a woman who's one or two months' pregnant, took the fetus, wrapped it up in a hard shell, and then threw it out into the environment for one year, 10 years, 50 years.''

One seed turned out to be 1,288 years old, according to carbon-dating. Even factoring in the imprecision of carbon-dating - give or take nearly 300 years - the seed had settled into the lake centuries before Marco Polo reached China.

While the sprouting seeds were thought to be important, and Shen-Miller presented the results at a meeting at the time, the research was not published until now.

Last year she gave a 95-year-old seed to Clarke, a specialist on aging. His research has focused on an enzyme called MT - short for L-isoapartyl methyltransferase - that repairs kinks that periodically appear in strands of proteins. MT exists in most creatures, including bacteria, humans and plants.

Clarke found the enzyme in the lotus seed as well: ``If this enzyme was not there, then you'd have to say `There's something wrong with the story.''' Surprisingly, the enzyme appeared as robust as that found in modern-day seeds, he said.



 by CNB